Cyanine3 carboxylic acid

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COO/COA

OCY301

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Cyanine3 carboxylic acid

suitable for HPLC, ≥95%

Synonym(s): Cy3-COOH

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Pack Size	SKU	Availability	Price	Quantity
1mg	OCY301-1mg	In stock	$99.00	- +
5mg	OCY301-5mg	In stock	$189.00	- +
10mg	OCY301-10mg	In stock	$299.00	- +
25mg	OCY301-25mg	In stock	$369.00	- +
50mg	OCY301-50mg	In stock	$626.00	- +

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Product Information

General Properties

Other Properties

Description

Safety Information

Product Information

CAS Number	1361402-15-4 (zwitterionic form), 1032678-01-5 (hydrochloride salt), 1251915-29-3 (iodide salt)
Linear Formula	C₃₀H₃₇ClN₂O₂
Molecular weight	493.08
Beilstein
EC Number
MDL Number	MDL
PubChem CID

General Properties

Purity	95%
Appearance	Red powder
Solubility	Freely soluble in methanol, chloroform, DMSO, DMF, and other organic solvents; slightly soluble in water.
Purity Testing Method	HPLC
Structural Identification Method	NMR/MS
Storage Conditions	−20 °C, keep in dark place.

Other Properties

DESCRIPTION

Cyanine3 Carboxylic Acid is a non-activated, non-sulfonated fluorescent dye featuring a terminal carboxyl group. It displays strong orange-red fluorescence and is soluble in polar organic solvents (e.g., DMSO, DMF), though poorly miscible in aqueous solutions. This compound serves as a non-reactive reference fluorophore for calibration, negative controls, or as a precursor for synthesizing activated derivatives.
For covalent conjugation to amine-containing biomolecules (e.g., proteins, peptides), use Cyanine3 NHS ester or its water-soluble sulfonated variant (sulfo-Cyanine3 NHS ester). Store under anhydrous conditions, shielded from light.

SAFETY INFORMATION

Symbol GHS
Hazard Code
Risk Statements
Safety Statements
RIDADR
WGK Germany
RTECS
F
Hazard Class
Packing Group
HS Code
Toxicity
Autoignition Temperature

1. Xue, M.; Wei, W.; Su, Y.; Johnson, D.; Heath, J.R. Supramolecular Probes for Assessing Glutamine Uptake Enable Semi-Quantitative Metabolic Models in Single Cells. Journal of the American Chemical Society, 2016, 138(9), 3085–3093. doi: 10.1021/jacs.5b12187

2. Kwok, S.J.J.; Choi, M.; Bhayana, B.; Zhang, X.; Ran, C.; Yun, S.-H. Two-photon excited photoconversion of cyanine-based dyes. Scientific Reports, 2016, 6, 23866. doi: 10.1038/srep23866

3. Melle, A.; Balaceanu, A.; Kather, M.; Wu, Y.; Gau, E.; Sun, W.; Huang, X.; Shi, X.; Karperien, M.; Pich, A. Stimuli-Responsive Poly(N}-vinylcaprolactam-co-2-methoxyethyl acrylate) Core-Shell Microgels: Facile Synthesis, Modulation of Surface Properties and Controlled Internalisation into Cells. Journal of Materials Chemistry B, 2016, 4(30), 5127–5137. doi: 10.1039/c6tb01196a

4. Soni, K.S.; Lei, F.; Desale, S.S.; Marky, L.A.; Cohen, S.M.; Bronich, T.K. Tuning polypeptide-based micellar carrier for efficient combination therapy of ErbB2-positive breast cancer. Journal of Controlled Release, 2017, 264, 276–287. doi: 10.1016/j.jconrel.2017.08.038

5. Mattila, J.T.; Beaino, W.; Maiello, P.; Coleman, M.T.; White, A.G.; Scanga, C.A.; Flynn, J.A.; Anderson, C.J. Positron Emission Tomography Imaging of Macaques with Tuberculosis Identifies Temporal Changes in Granuloma Glucose Metabolism and Integrin α4β1-Expressing Immune Cells. Journal of immunology, 2017, 199(2), 806–815. doi: 10.4049/jimmunol.1700231

6. Deshmukh, R.; Biehs, S.-A.; Khwaja, E.; Galfsky, T.; Agarwal, G.S.; Menon, V.M. Long-range resonant energy transfer using optical topological transitions in metamaterials. ACS Photonics, 2018, 5(7), 2737–2741. doi: 10.1021/acsphotonics.8b00484

7. Nam, J.; Lim, H.-K.; Kim, N.H.; Park, J.K.; Kang, E.S.; Kim, Y.-T.; Heo, C.; Lee, O.-S.; Kim, S.-G.; Yun, W.S.; Suh, M.; Kim, Y.H. Supramolecular Peptide Hydrogel-Based Soft Neural Interface Augments Brain Signals through Three-Dimensional Electrical Network. ACS Nano, 2020, 14(1), 664–675. doi: 10.1021/acsnano.9b07396

8. Nishiyama, K.; Maeki, M.; Ishida, A.; Tani, H.; Hisamoto, H.; Tokeshi, M. Simple Approach for Fluorescence Signal Amplification Utilizing a Poly(Vinyl Alcohol)-Based Polymer Structure in a Microchannel. ACS Omega, 2021, 6(12), 8340–8345. doi: 10.1021/acsomega.1c00057

9. Mattila, J. T.; Beaino, W.; White, A. G.; Nyiranshuti, L.; Maiello, P.; Tomko, J.; Frye, L. J.; Fillmore, D.; Scanga, C. A.; Lin, P. L.; Flynn, J. L.; Anderson, C. J. Retention of ⁶⁴Cu-FLFLF, a Formyl Peptide Receptor 1-Specific PET Probe, Correlates with Macrophage and Neutrophil Abundance in Lung Granulomas from Cynomolgus Macaques. ACS Infect. Dis., 2021, 7(8), 2264–2276. doi: 10.1021/acsinfecdis.0c00826

10. Xu, S.; Zhang, P.; Heing-Becker, I.; Zhang, J.; Tang, P.; Bej, R.; Bhatia, S.; Zhong, Y.; Haag, R. Dual Tumor- and Subcellular-Targeted Photodynamic Therapy Using Glucose-Functionalized MoS2 Nanoflakes for Multidrug-Resistant Tumor Ablation. Biomaterials, 2022, 290, 121844. doi: 10.1016/j.biomaterials.2022.121844

Key Documents

OCY301

Symbol GHS

Hazard Code

Risk Statements

Safety Statements

RIDADR

WGK Germany

RTECS

F

Hazard Class

Packing Group

HS Code

Toxicity

Autoignition Temperature

1. Xue, M.; Wei, W.; Su, Y.; Johnson, D.; Heath, J.R. Supramolecular Probes for Assessing Glutamine Uptake Enable Semi-Quantitative Metabolic Models in Single Cells. Journal of the American Chemical Society, 2016, 138(9), 3085–3093. doi: 10.1021/jacs.5b12187

2. Kwok, S.J.J.; Choi, M.; Bhayana, B.; Zhang, X.; Ran, C.; Yun, S.-H. Two-photon excited photoconversion of cyanine-based dyes. Scientific Reports, 2016, 6, 23866. doi: 10.1038/srep23866

4. Soni, K.S.; Lei, F.; Desale, S.S.; Marky, L.A.; Cohen, S.M.; Bronich, T.K. Tuning polypeptide-based micellar carrier for efficient combination therapy of ErbB2-positive breast cancer. Journal of Controlled Release, 2017, 264, 276–287. doi: 10.1016/j.jconrel.2017.08.038

6. Deshmukh, R.; Biehs, S.-A.; Khwaja, E.; Galfsky, T.; Agarwal, G.S.; Menon, V.M. Long-range resonant energy transfer using optical topological transitions in metamaterials. ACS Photonics, 2018, 5(7), 2737–2741. doi: 10.1021/acsphotonics.8b00484

8. Nishiyama, K.; Maeki, M.; Ishida, A.; Tani, H.; Hisamoto, H.; Tokeshi, M. Simple Approach for Fluorescence Signal Amplification Utilizing a Poly(Vinyl Alcohol)-Based Polymer Structure in a Microchannel. ACS Omega, 2021, 6(12), 8340–8345. doi: 10.1021/acsomega.1c00057

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Key Documents

OCY301

Symbol GHS

Hazard Code

Risk Statements

Safety Statements

RIDADR

WGK Germany

RTECS

F

Hazard Class

Packing Group

HS Code

Toxicity

Autoignition Temperature

OCY311

Cyanine3 Trans-Cyclooctene

OCY310

Cyanine3 SH

OCY309

Cyanine3 amine

OCY308

Cyanine3 Biotin

OCY307

Cyanine3 DBCO

OCY306

Cyanine3 alkyne

OCY305

Cyanine3 azide

OCY304

Cyanine3 tetrazine

OCY303

Cyanine3 maleimide

OCY302

Cyanine3 NHS ester

1. Xue, M.; Wei, W.; Su, Y.; Johnson, D.; Heath, J.R. Supramolecular Probes for Assessing Glutamine Uptake Enable Semi-Quantitative Metabolic Models in Single Cells. Journal of the American Chemical Society, 2016, 138(9), 3085–3093. doi: 10.1021/jacs.5b12187

2. Kwok, S.J.J.; Choi, M.; Bhayana, B.; Zhang, X.; Ran, C.; Yun, S.-H. Two-photon excited photoconversion of cyanine-based dyes. Scientific Reports, 2016, 6, 23866. doi: 10.1038/srep23866

4. Soni, K.S.; Lei, F.; Desale, S.S.; Marky, L.A.; Cohen, S.M.; Bronich, T.K. Tuning polypeptide-based micellar carrier for efficient combination therapy of ErbB2-positive breast cancer. Journal of Controlled Release, 2017, 264, 276–287. doi: 10.1016/j.jconrel.2017.08.038

6. Deshmukh, R.; Biehs, S.-A.; Khwaja, E.; Galfsky, T.; Agarwal, G.S.; Menon, V.M. Long-range resonant energy transfer using optical topological transitions in metamaterials. ACS Photonics, 2018, 5(7), 2737–2741. doi: 10.1021/acsphotonics.8b00484

8. Nishiyama, K.; Maeki, M.; Ishida, A.; Tani, H.; Hisamoto, H.; Tokeshi, M. Simple Approach for Fluorescence Signal Amplification Utilizing a Poly(Vinyl Alcohol)-Based Polymer Structure in a Microchannel. ACS Omega, 2021, 6(12), 8340–8345. doi: 10.1021/acsomega.1c00057

omichem

SIGN UP & SAVE 10%

Applies to full-price items only. Online exclusive.

By submitting your email, you agree to:

Receive promotional emails from OMICHEM (unsubscribe anytime)

Our Terms of Use (including arbitration clause)

Data sharing with service providers as per our Privacy Policy